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time of injection seem to have been reported. Chan.ges, however, in syphilitic eruptions are re- markable. A roseolar syphilide increases its con- gestive redness and size and Generic Viagra Forum Uk may add to it macuhir spots. Papular syphilides show a kind of red zone surrciunding them and look irritated. The Jarish-Herxheimer phenomenon is peculiar. It Generic Viagra Forum Uk consists in increased redness and swelling 6i macules and the papules. Its significance has not vet been determined. Inasmuch, however, as it is a manifest disturbance of the lesions, \\'echselmann"s view may be correct, namely, that too little of the drug has been .given to destroy the Treponema pal- lidinn. hence its obvious activity in the lesions in resisting the drug. The clinical effect of salvarsan should be consid- ered in series Generic Viagra Forum Uk as to the period of the disease under treatment. In open lesions the Spirochceia pallida may disappear in from one to seven days. Sies-^- kind, Gerrone, and Huggenberg and Neisser have observed that during this period their common char- acteristics of activity, form, refringence. coils, and the like become altered. Generic Viagra Forum Uk The serum test is all im- portant in watching the disappearance of the in- fection ; as a rule, the chan.ge is constant and regu- lar and in from two to six weeks a positive becomes negative. In the nervous lesions this change is a little less marked. Chancres, condylomata, and other secondary lesions Generic Viagra Forum Uk of syijhilis heal with great rapidity. Second- ary signs upon the skin disappear as a rule with a RVT/XA: SALIARSAX THERAPEUTICS. 5I5 similar f)rojnptness. Forms, however, with mixed infection, such as rupial syphilides. are much slow- er and require local treatment in addition. Tertiary lesions, particularly gummata, heal with renewed activity. Tertiary lesions with pain, such as peri- ostitis and in the nervous system, appear to be little affected by the injection unless it be that the process is brought to a standstill. Generic Viagra Forum Uk Even if this proved to be true in the future, the method will be acknowledged one of great value because in cases with early diagnosis subsequent ravages of syphilis in the nervous system will be stopped. All this, however, seems to be too good to be true. Time and only time will tell. Syphilis of important organs. i)articularly the liver and the kidneys, is undtiubtedly benefited by injections of 606 accord- ing to the literature. When the Generic Viagra Forum Uk eyes are attacked, the medicine may not be advisedly given in all forms. The theory that optic neuritis prevented its administration was probably evolved from the fact that some injections were harmful. It has been found, however, that these injections usually contained wood alcohol which was used in some of the original methods for preparing the medicine for injection. In hereditary syphilis the medicine seems to be of value. Pregnant women, nurslings, and syphi- litic children of tender years have been injected. The writer has had four cases, in two husbands and their wives, all giving positive blood tests and a history of repeated miscarriages of syphilitic children. It is too early to give the final data con- cerning these cases so far as the results are con- cerned. (To be continued.) THE PRESENT STATUS OF S.\LV.\RS.-\X THER- APEUTICS.* By a. G. Rytix.a, M. D., Baltimore. 1 1 roTi: li.c- Departments of Genitourinary Surger.v. Dr. Charles F. Bcvau. chief, and Experimental Medicine of the College of Physicians and Surgeons, Dr. C. E. Simon, chief.) The last decade stands preeminent for the many manurnental advances that scientific medicine has made in the studies of syphilis. Within the brief expanse of six years, there took place Metchin- koff's and Roux's' discovery of the transmissibility of syphilis to animals, the immortal disc(;very of Shiroclufta pallida by .Schaudinn and Hoffmann.- the discovery of the inoculability of syphilis to other animals besides the ape sj^ecies, by Bertarclli and \eisser." etc., the discovery of the complement fix- ation test by Wassermann,* and finally, it seems possible, we are on the very threshold of the realization of the dream of sanitarians for ages, namely : the conquest of syphilis. For a k)ng time Ehrlich has Generic Viagra Forum Uk been working on the theory, that there exists a specific chemical affinity between specific living cells and specific chemical substances. This idea is embraced in the term ciiemothcrapy. a Generic Viagra Forum Uk new invader in the domains of medicine, and one 'that is Generic Viagra Forum Uk destined to loom mighty and powerful Generic Viagra Forum Uk in the medical advances and achieve- •Rcad li.v invitation at the meeting of the llalmr.orc City .Medical Society. I'tl.niary 17. 1911, nients that the future has in store for the human race. \\'hile Ehrlich is working along these lines, I'hlenhuth^ and others are successfully experiment- ing with atoxyl in the treatment of certain protozoon infections, particularly, dourine (a trypanosome infection of horses), chicken spirillosis, and syph- ilis. For the latter disease, both hvmian and animal, they found injections of atoxyl to possess both a prophylactic and curative effect, but on account of its high toxicity and the frequency of optic nerve atrophy and blindness, it had to be used with ex- treme caution. Ehrlich now appears upon the scene, and determines to remove its toxic effect and improve it in every possible manner. He first worked out its true chemical constitution, which was entirely different from that which Bechamp its discoverer, thought it to be. He discovered also that it was a very stable compound and capable of