Viagra 100mg Vs 50mg | OVERNIGHT Delivery!







































tube it has no effect, and it is only after it gets into the body fluids and tissues and there undergoes certain reduction processes that it becomes effec- tive. It is theorized that in this state it kills a cer- tain number of spiroch^tx. in consequence of which there occurs a liberation of endotoxines which cause a large antibody formation, sufficient to kill the remaining Spirochcct(c palUdtc and the healing of the syphilitic processes. Ehrlich^'' Viagra 100mg Vs 50mg believes that salvarsan is specific and advances the following reasons: i. The disappear- ance of Spirochcctce pallidcr in twenty-four to forty- eight hours. If they do not disappear one of three conditions obtains : the dose has been insufficient, or there has been defective absorption, or we are dealing with a strain of spirochsetse that are arsenic fast. 2. The building of specific antibodies. The first observations of this character were reported bv Taege^' and Duhot," who favorably influenced a congenitally syphilitic child by the injection of sal- varsan solution into the mother. Examination of the mother's milk showed no trace of organic ar- senic and only minimum amounts of inorganic ar- senic. Marinescu, Aleirowsky," Plant,-" Scholtz.-^ Michaelis, and others, have shown that the scrum of patients cured with salvarsan has a curative ef- fect on syphilitic processes, especially of the newly born. Ehrlich-"- says that this method of treating congenital syphilis, vie, through the agency of the mother's milk or the injection of patierft's Viagra 100mg Vs 50mg serum should be recommended, because if you inject a so- lution of salvarsan the tremendous reduction of Spirochcctce pallida: may cause the liberation of t -^ much endotoxine, which might result fatally. 3. Its effect in causing the abolition of the W'as- sermann reaction. 4. Its effect in relieving pain. The severe pain in certain luetic conditions of the throat and tongue, etc., Viagra 100mg Vs 50mg is relieved in a few hours following the injec- tion. The only explanation is that there must have been a neutralization of the secretion products of Viagra 100mg Vs 50mg the spirochsetae, just like a toxine by an antitoxine. as in that brief interval sufficient anatomical repair could not have taken place. DOSAGE. We do not yet know how much it is possible t- give human beings without causing harm. If we could judge by animal experimentation it would be possible to give as high as five to six grammes without causing injur)-. Rut it is probable that man is more susceptible than the most susceptible of ani- mals, and three grammes will be as high as will ever be given with safety. If this proves Viagra 100mg Vs 50mg true, we can readily realize how ridiculously inadequate the present dosage is, varying between 0.3 and 0.8 gramme. As high as 1.2 gramme has been injected intravenously in one dose without causing any un- toward effect. Many observers vary their doses according to the lesions and the stage of the dis- ease, giving large Viagra 100mg Vs 50mg doses in primary and secondary April 29. !9IJ) RVTIX.^: SALfARSAX THERAPEUTICS. lesions, small doses in malignant and tertiary le- sions. In some of the primary cases, especially those with the hard indurated chancre, it may be neces- sary to giye Viagra 100mg Vs 50mg a second injection on account of the obliterative endarteritis present, \yhich prevents the salvarsan from reaching every part of the lesion. There is no objection to repeating the injection, as was first thought, should it become necessary. Early in his work Ehrlich learned that if you give repeated small injections of a drug, the organisms soon develop Viagra 100mg Vs 50mg a toleration for the drug, which is also transmitted to the progeny. On this account he has labored to produce Viagra 100mg Vs 50mg a compound, which would with one blow kill all of the organisms, and at the same time leave the body free and uninjured ; in other words, parasitotropic, but not organotropic. This he has called his Therapeia sterilisans magna. Margulies-" has made repeated attempts to produce a tolerant strain of Spirochceta paUidcc to salvarsan and has failed. Furthermore, he has not noted any development of supersensitiveness in animals who have received repeated injections of the drn,g. This holds true also for human beings. As high as seven injections have been given to a human be- ing without harm resulting. Viagra 100mg Vs 50mg In our own work we have noted that the reaction is much less intensive after the second injection. On this account if the reaction was not very marked at the time of the first injection, at the time Viagra 100mg Vs 50mg of the second we give a larger dose. Kfomayer-' and. more recently. Lesser,-^ think Ehrlich's Therapeia .^tcrilisaus magna is impracti- cal. Unlike recurrent fever, in syphilis the organ- isms are not mostly in the circulation, but in the Viagra 100mg Vs 50mg position of spirochstse rests in various portions of the body, and you need a prolonged, protracted ef- fort in order to get at the spirochaetas deposits. In order to prolong the effect. Kromayer gives intra- muscuif.r injections of salvarsan o.i to 0.2 gramme in pararTin oil every day or ever>' other day until 1.2 gramme is taken. Ehrlich-^ states that in ad- vanced stages of recurrent fever, extensive tissue changes are present, and one dose is sufficient to sterilize. Therefore, the same should hold true of syphilis. RK.VCTIVE PHENOME.X.N FOLLOWING THE IXJECTIONS. These consist of chills, fever, sweats, headache, nausea, vomiting, diarrhoea, thir.st, rapid pulse, leu- cocytosis. etc. We have not observed Her.xheimer's reaction in any of our seventy-five intravenous cases, but have seen in several the development of various kinds of eruptions. One patient developed a diffuse generalized eruption, which exactly simu- laterl measles, .\nother developed at the site of the intramuscular injection a diffuse urticarial rash, another showed a general urticarial eruption. The leucocvtosis which follows the injection may reach as high as tliirty-eight thousand. Neisser^^ avers that the development of fever following the injec-