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that "naked" neutral fat, as we may call it to pre- serve our unity of thotight, is not absorbed by cell membranes. Give another coating Viagra Prescriptions Per Year to its granules and in it goes, and when it takes off its overcoat in- side the cell — there it is. I have had occasion Viagra Prescriptions Per Year to point out the importance of the work of Professor Albrecht for our concep- tion of intracellular structure and dynamics and Aschoff does justice to his conception of the dyna- mics of the circulation in the connective tissue. In 1907, at the Dresden meeting of the German Patho- logical Society, he drew attention to the behavior of many of the drops in the lymph spaces of the tadpole's tail when pressed out into water or a weak salt solution ; like the scolices of acne, many of them still present in the lymph spaces projecting inward, they showed simple or compound myelin figures continually derived from the wall Viagra Prescriptions Per Year (of the spaces). He continues: ■'The surprising fact emerges from this that a sim- ilar structural plan, such as we are already acquaint- ed Viagra Prescriptions Per Year with in much finer form in the cell, is found in the connective tissue of the tadpole's Viagra Prescriptions Per Year tail ; that is to say, the formation of large Viagra Prescriptions Per Year drops which are made up on the surface of some myelin producing sub- stance (he means by this some lipoid), which con- tains inside some fluid watery solution," "They represent thereby an osmotic reservoir lined with a lipoid sheeting."^^ Indeed, Albrecht imagined, for the explanation of the movement of the lymph and the cells which wander with it through the lymph spaces, that these spaces are in fact lined with a coating of a lipoid nature. We may extend the conception a little. As the lipoid coated bacillus slips along the lipoid washed endothelial walls of the lymph spaces, as the intestinal^^ contents glide downward to the sigmoid flexure, we may believe, from what we shall subsequently learn of the immunological side of the lipoids, that it is to the nature of the lipoid coating of the channels, as I believe it is to the lipoid nature of the contents of the tonsillar epi- thelium, that man owes in part his immunity to bac- terial toxin or intestinal autotoxin or to bacteria! tonsillar invasion. It is easy to understand from what I have said in regard to the tenuity of the lipoid film, necessary to supply an efficient characteristic tension to a sur- face, that such a coating would defy direct detec- tion, but Albrecht's conception of the wall linings of the infection and nutrition routes in the connec- tive tissue, will find its justification in Viagra Prescriptions Per Year ncent dis- closures as to the composition of the external phases or membranes of cell protoplasm, with which I have in previous papers dealt to some extent and Viagra Prescriptions Per Year to which further allusion will be made. When one remembers how liquid crystals can be made to glide along glass surfaces by virtue of their own varying internal molecular structure, we "yerhandlungen der Deulschen Pathologitchen Gesellschaft, 1907. p. 4. "For an account of "The precipitogenic ferment of the fxccs as well _ as of the cellular coating of the gastrointestinal tract," lee Brezina and Ranzi, Zeitschrift fiir ImmumlStsforschung, Viagra Prescriptions Per Year iv, p. 375, 1910. 768 WRIGHT: FATS AXD LIPOIDS. IV [New York Medical Journ.^ may understand how much more labile an agent of convection they become when they creep along sur- faces which themselves vary with every breath of chemical Viagra Prescriptions Per Year change. In the tangled skein of vital action it is difficult to maintain any conformity to the sequence de- manded by the arbitrary divisions of biological sci- ence into acts of nutrition and decay, of immunity and infection, of cell division and cell annihilation, if one attempts to trace out, without Viagra Prescriptions Per Year teleological or anthropomorphic bias, the different phases of phy- sical and chemical changes in the cells. They all hang together, yet some heads of discourse are nec- essary, and I may, as well as of any other, say some- thing first of the apparent part the lipoids play in the process of caryocinesis, especially as suggested in connection with my own work. In the first article on the neutral fat in the lymph- ocytes I have drawn attention to its demonstration exclusively or almost so in cells having two or more, usually two separate nuclei, while soap and cholesterin show chiefly in cells in which one nu- cleus is found. I am not concerned here with the discussion as to whether wc ought to look upon these cells as true lymphocytes or as lymphocytes changed into plasma cells. In these cells it often happens that the stimulus to cell division ceases to be operative after nuclear division and the cysto- plasm remains undivided, exhibiting multiple nu- clei. This is the stage par excellence in which I have noted regularly the presence in the cytoplasm of neutral fat. In the study of the lecithin it seemed apparent that that lipoid was associated with the neutral fat at this stage," but it was also present, which was not the case for the neutral fat, in the act of nuclear division and during cytoplasmic di- vision also. After the completion of the act of cyto- plasmic division the lipoids showing are cholesterin and soap. Let us at once turn to the admirable paper on Surface Tensions in Relation to Cellular Processes, by Professor A. B. MacCallum, which has recently appeared," and there we learn that: "In cell and nuclear division surface tension operates as a force, the action of which cannot be completely understood until we know more of the part played by the cen- trosome and centrosphere. Viagra Prescriptions Per Year That this force takes part in cell reproduction has already been suggest- ed by Brailsford Robertson. He has devised an in- genious experiment to illustrate its action. If a thread moistened with a solution of a bas; is laid across a drop of oil in which is dissolved some free